Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumours

摘要: Kim T H, Y K, Kwon Y, Heo J Kang G & An H (2010) Histopathology57, 734–743 Deregulation of miR-519a, 153, and 485-5p its clinicopathological relevance in ovarian epithelial tumours Aims:  The pathological clinical significance aberrant miRNA expression tumours has yet to be adequately documented. aim this study was assess the differences human according histological subtype, determine whether miRNAs are potential diagnostic prognostic markers cancers. Method results:  profiles 103 were evaluated. Via a bead-based microarray, five selected which expressed differentially malignant serous from borderline benign tumours, including (miR)-519a, miR-18b (up-regulation) miR-153, miR-511 miR-485-5p (down-regulation). We conducted quantitative real-time reverse transcription–polymerase chain reaction (qRT–PCR) order confirm that these different subtypes compared between subsets. correlated with parameters. miR-153 four major histotypes cancers (P < 0.05), suggests they might importance as biomarkers. Down-regulation significantly FIGO grade 3 (P < 0.05). up-regulation miR-519a advanced stage results Kaplan–Meier survival analysis indicated higher late carcinoma associated poor progression-free (P = 0.0058). Conclusions:  A significant correlation detected deregulation specific types miRNAs, such miR-485-5p, variables well cancers. Hence, may perform functions or