Low-voltage-activated T-type Ca2+ channel inhibitors as new tools in the treatment of glioblastoma: the role of endostatin.

摘要: Ca2+ plays a key role in intracellular signaling and controls various cellular processes such as proliferation, differentiation, cell growth, death, apoptosis. Aberrant changes levels can promote undesired proliferation migration are therefore associated with certain tumor types. Many research groups have suggested potential for voltage-gated channels the regulation of growth progression, particularly T-type due to their unique biophysical properties. expressed normal tissues throughout body different types tumors breast carcinoma, retinoblastoma, neuroblastoma, glioma. It has been demonstrated that increased functional expression α1 subunit abnormal glioblastoma cells. As such, siRNA-mediated knockdown decreases these Moreover, pharmacological blockade significantly growth. In this review, we focus on use channel blockers treatment cancers, highly proliferative glioblastoma. We conclude endostatin serve therapeutic tool whose depends expression.