Functional role of T-type calcium channels in tumour growth and progression: prospective in cancer therapy.
作者： Giorgio Santoni , Matteo Santoni , Massimo Nabissi
DOI: 10.1111/J.1476-5381.2012.01908.X
关键词:
摘要: T-type Ca2+ channels represent a specific channel family overexpressed in different types of tumours. Their involvement controlling the proliferation, angiogenesis and invasion tumour cells, has been partially clarified. The article by Zhang et al. this issue BJP provides first evidence anti-tumoural effects endostatin (ES) U87 glioma cells. He demonstrated that ES or mibefradil (a L/T-type calcium blocker), reduces proliferation migration cells channel-dependent manner. However, difference blocking effect on expression as compared with its ability to inhibit migration, supports idea broader T/L-type-independent blocker. Overall, these findings provide new insights for future development novel class anti-T-type blockers therapy glioblastoma. LINKED ARTICLE This is commentary al., pp. 1247–1260 issue. To view paper visit http://dx.doi.org/10.1111/j.1476-5381.2012.01852.x
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