The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I

摘要: Glioblastoma multiforme (GB) is the most malignant primary brain tumor in humans, with an overall survival of approximatively 15 months. The molecular heterogeneity GB, as well its rapid progression, invasiveness and occurrence drug-resistant cancer stem cells, limits efficacy current treatments. In order to develop innovative therapeutic strategy, it mandatory identify characterize new players responsible for GB phenotype. this study, RNA-binding ubiquitin ligase MEX3A was selected from a gene expression analysis performed on publicly available datasets, assess biological still-unknown activity tumorigenesis. We find that strongly up-regulated specimens, correlates very low protein levels RIG-I, suppressor involved differentiation, apoptosis innate immune response. demonstrate binds RIG-I induces ubiquitylation proteasome-dependent degradation. Further, genetic depletion leads increase results suppression cell growth. Our findings unveil novel mechanism tumorigenesis suggest promising targets GB.