Prevalence of Vertebral Fractures by Semiautomated Morphometry in Patients with Ankylosing Spondylitis

摘要: Objective. Ankylosing spondylitis (AS) is a chronic inflammatory disease mainly affecting the axial skeleton and characterized by ossification of spinal disc, joints, ligaments leading to progressive ankylosis. Vertebral osteoporosis recognized feature AS. Studies have confirmed moderate high prevalence vertebral fractures with extremely varying ranges in patients Our objective was estimate representative Spanish population AS using validated semiquantitative method, MorphoXpress®. Methods. Patients were randomly selected from 10 initial participating centers National Registry Spondyloarthropathies (REGISPONSER) consecutive sampling. All fulfilled New York modified criteria for had baseline thoracolumbar radiograph. A prevalent fracture defined according Genant classification criteria. Results. The estimated 32.4% (95% CI 25.5%–39.3%). majority localized thoracic segment (n = 100; 82.%) mild 79; 64.8%). In logistic regression analysis, age (odds ratio per year 1.05, 95% 1.03–1.08, p < 0.001), duration (OR 1.03, 1.01–1.06, 0.011), Bath Spondylitis Functional Index score 1.16, 1.03–1.30, 0.015), Radiographic Index-TS 1.25, 1.12–1.39, wall-occiput distance cm 1.15, 1.08–1.23, 0.001) all associated fracture. Conclusion. Semiquantitative methods are needed improve diagnosis order start early treatment avoid complications arising osteoporosis.