MicroRNA expression patterns in the malignant progression of gliomas and a 5-microRNA signature for prognosis

摘要: MicroRNAs (miRNAs) are directly involved in the progression various cancers. To date, no systematic researches have been performed on expression pattern of miRNA during from low grade gliomas to anaplastic or secondary glioblastomas and those prognostic miRNAs glioblastomas. In present study, high-throughput microarrays were used measure levels 116 samples different stages glioma. We found that totally altered when progressed However, similar level. Furthermore, we developed a five-miRNA signature (two protective miRNAs-miR-767-5p, miR-105; three risky miRNAs: miR-584, miR-296-5p miR-196a) could identify patients with high risk unfavorable outcome regardless histology type. It should be highlighted can also who had TCGA Proneural glioblastomas, but not Neural, Classical Mesenchymal Taken together, our results demonstrate patterns malignant novel classifier, signature, serve as marker for patient stratification gliomas, Secondary