hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells.

摘要: MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate protein expression by cleaving or repressing the translation of target mRNAs. In mammal animals, their function mainly represses mRNAs transcripts via imperfectly complementary to 3' UTR Several miRNAs have been recently reported be involved in modulation glioma development, especially some up-regulated miRNA, such as hsa-miR-21 and hsa-miR-221. However, here we down-regulated hsa-miR-181a hsa-miR-181b hsa-miR-181 family were also oncogenesis glioma. Our studies showed functioned tumor suppressors which triggered growth inhibition, induced apoptosis inhibited invasion cells. Furthermore, tumor-suppressive effect cells was more apparent than hsa-miR-181a. These findings suggest aberrantly may critical factors contribute malignant appearance human gliomas.