Natural history, risk factors and clinical features of primary hypogonadism in ageing men : Longitudinal Data from the European Male Ageing Study

摘要: Objective: In ageing men, the incidence and clinical significance of testosterone (T) decline accompanied by elevated luteinizing hormone (LH) are unclear. We describe natural history, risk factors features associated with development biochemical primary hypogonadism (PHG, T 9·4U/l) in men. Design, Patients Measurements: A prospective observational cohort survey 3,369 community-dwelling men aged 40-79 years, followed up for 4·3 years. Men were classified as incident (i) PHG (eugonadal [EUG, ≥ 10·5 nmol/l] at baseline, follow-up), persistent (p) (PHG baseline pEUG (EUG follow-up) reversed (r) EUG follow-up). Predictors changes analysed regression models. Results: Of 1,991 comprising analytical sample, 97·5% had pEUG, 1·1% iPHG, pPHG 0·3% rPHG. The was 0·2%/year. Higher age (>70 years) [OR 12·48 (1·27-122·13), P = 0·030] chronic illnesses 4·24 (1·08-16·56); 0·038] predicted iPHG. Upon transition from to PHG, erectile function, physical vigour haemoglobin worsened significantly. decreased morning erections, sexual thoughts increased insulin resistance. Conclusions: Primary testicular failure is uncommon old illness. Some attributable androgen deficiency, but not others, who developed PHG. Whether replacement can improve and/or function elderly merits further study.