Clinical applications of pharmacogenomics guided warfarin dosing

摘要: Aim of the Review To assess state literature concerning pharmacogenomic testing in patients requiring vitamin K antagonists, specifically warfarin. Method We conducted a search MEDLINE and International Pharmaceutical Abstracts using following words: warfarin, pharmacogenetic, pharmacogenomic. The results were reviewed by authors papers warfarin dosing procured reviewed. Additionally bibliographies also examined for other studies. focused on clinical trials use dosing. Results Although numerous studies have demonstrated that significant portion variability can be explained genetic polymorphisms, few prospective been examine integration this information practical situations. Those have, shown improves initial estimates decreases need frequent clinic visits laboratory testing. Data showing reduction serious bleeding events is sparse. Cost-effectiveness analyses generally small but positive effect with receiving Conclusion Several more accurate schemes. Pharmacogenomic time to therapeutic international normalized ratio while fewer adjustments. Patients who require higher or lower than usual doses seem benefit most. cost-effectiveness as well preventing outcomes such thrombosis are not yet elucidated. Pharmacists, especially those community setting play role new technology educating prescribers testing, developing protocols incorporate its use.