Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/SCID engrafting potential
作者： AMS Cheung , TSK Wan , JCK Leung , LYY Chan , H Huang
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摘要: Aldehyde dehydrogenase (ALDH) activity is used to define normal hematopoietic stem cell (HSC), but its link leukemic cells (LSC) in acute myeloid leukemia (AML) currently unknown. We hypothesize that ALDH AML might be correlated with the presence of LSC. Fifty-eight bone marrow (BM) samples were collected from (n=43), lymphoblastic (ALL) (n=8) and cases (n=7). In 14 cases, a high SSC(lo)ALDH(br) population was identified (ALDH(+)AML) (median: 14.89%, range: 5.65-48.01%), majority coexpressing CD34(+). another 29 there undetectable (n=23) or rare (< =5%) (n=6) (ALDH(-)AML). Among other clinicopathologic variables, ALDH(+)AML significantly associated adverse cytogenetic abnormalities. CD34(+) BM engrafted better NOD/SCID mice (ALDH(+)AML: injected 21.11+/-9.07%; uninjected 1.52+/-0.75% vs ALDH(-)AML: 1.77+/-1.66% (P=0.05); 0.23+/-0.23% (P=0.03)) engrafting showing molecular aberrations identical original clones. Normal contained small 2.92%, 0.92-5.79%), none ALL showed this fraction. conclusion, denote primitive LSC confer an inferior prognosis patients.
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