Resolution of infertility and number of children: 1386 couples followed for a median of 13 years.

摘要: STUDY QUESTION How common were children among infertile couples? SUMMARY ANSWER A total of 61.7% couples presenting for care subsequently had live born 13.1 years after first being clinically assessed, with a mean 1.7 those who at least one. WHAT IS KNOWN ALREADY While the prognoses undertaking specific treatments have been well described, less is known about not undergoing these or number children. This information necessary decision-making in many individual cases; knowing this has cited by patients and clinicians as impeding implementation care. DESIGN, SIZE, DURATION The sole provider specialist fertility two southern-most regions New Zealand enroled 1386 from 1998 to 2005 longitudinal study follow-up on all births until end 2014. Couples followed median 1.1 was years. PARTICIPANTS/MATERIALS, SETTING, METHODS Clinic-collected data linked national maternity extend past clinical contact. primary outcome Hurdle regression used investigate factors associated resolving infertility MAIN RESULTS AND THE ROLE OF CHANCE Infertility resolved birth (95% CI 59.1-64.2%) couples; just over half treatment-dependent. Among their infertility, 55.6% (52.2-58.9%) one additional child 1.7. female age strongly influenced outcomes, one-third women aged 40-41 child, significantly than late 30s. lowest levels resolution occurred ≥42 years, >4 BMI ≥ 35 kg/m2. Moderate obesity did affect outcomes. LIMITATIONS, REASONS FOR CAUTION main limitation insufficient male factor It also possible that treatment-dependent could be higher more recent cohorts increased use ART. WIDER IMPLICATIONS FINDINGS Outcomes are comparable seen other studies high-income countries despite relatively low contribution prognosis most positive suggests will require treatment. Further research needed inform best practice early forties moderate obesity, develop prediction models relevant initial management infertility. FUNDING/COMPETING INTEREST(S) co-funded University Otago PhD Scholarship Department Women's Children's Health, Otago. There no competing interests declare.