摘要: Apoptosis, or programmed cell death, plays an essential role in controlling number many developmental and physiologic settings as well chemotherapy-induced tumor killing. It is a genetically regulated biologic process that by the ratio of proapoptotic proteins over antiapoptotic proteins. Researchers have recently begun using apoptosis inducers cancer therapy. In studies, attempts been made to induce triggering necrosis factor-related apoptosis-inducing ligand receptor Bcl-2 family proteins, caspases, inhibitors apoptotic Most these agents are still preclinical phase development because their low efficacy potential for resistance. However, results obtained with other promising. This chapter reviews inducing anticancer drugs clinical trials.
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sci-hub.se 参考文章(113)
Martin Holcik, Hilary Gibson, Robert G. Korneluk, XIAP: apoptotic brake and promising therapeutic target. Apoptosis. ,vol. 6, pp. 253- 261 ,(2001) , 10.1023/A:1011379307472
Sela B, [Survivin: anti-apoptosis protein and a prognostic marker for tumor progression and recurrence]. Harefuah. ,vol. 141, pp. 103- ,(2002)
Ryungsa Kim, Kazuaki Tanabe, Yoko Uchida, Manabu Emi, Hideki Inoue, Tetsuya Toge, Current status of the molecular mechanisms of anticancer drug-induced apoptosis. The contribution of molecular-level analysis to cancer chemotherapy. Cancer Chemotherapy and Pharmacology. ,vol. 50, pp. 343- 352 ,(2002) , 10.1007/S00280-002-0522-7
Julian Adams, Vito J. Palombella, Peter J. Elliott, Proteasome inhibition: a new strategy in cancer treatment. Investigational New Drugs. ,vol. 18, pp. 109- 121 ,(2000) , 10.1023/A:1006321828515
Henning Walczak, Robert E. Miller, Kiley Ariail, Brian Gliniak, Thomas S. Griffith, Marek Kubin, Wilson Chin, Jon Jones, Anne Woodward, Tiep Le, Craig Smith, Pam Smolak, Raymond G. Goodwin, Charles T. Rauch, JoAnn C.L. Schuh, David H. Lynch, Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo Nature Medicine. ,vol. 5, pp. 157- 163 ,(1999) , 10.1038/5517
Tetsuhisa Yamamoto, N. Tanigawa, The role of survivin as a new target of diagnosis and treatment in human cancer. Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan. ,vol. 34, pp. 207- 212 ,(2001) , 10.1007/S007950100017
S. de Jong, T. Timmer, F.J. Heijenbrok, E.G.E. de Vries, Death receptor ligands, in particular TRAIL, to overcome drug resistance. Cancer and Metastasis Reviews. ,vol. 20, pp. 51- 56 ,(2001) , 10.1023/A:1013112624971
Ayman Saleh, Srinivasa M. Srinivasula, Levent Balkir, Paul D. Robbins, Emad S. Alnemri, Negative regulation of the Apaf-1 apoptosome by Hsp70 Nature Cell Biology. ,vol. 2, pp. 476- 483 ,(2000) , 10.1038/35019510
Francesca DiStefano, David Robertson, Paul Andrew Clarke, Isabelle Hostein, Paul Workman, Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis. Cancer Research. ,vol. 61, pp. 4003- 4009 ,(2001)
Len Neckers, Theodor W. Schulte, Edward Mimnaugh, Geldanamycin as a Potential Anti-Cancer Agent: Its Molecular Target and Biochemical Activity Investigational New Drugs. ,vol. 17, pp. 361- 373 ,(1999) , 10.1023/A:1006382320697