Eradication of Helicobacter pylori with clarithromycin and omeprazole.

摘要: Clarithromycin, a new and well tolerated, acid stable macrolide antibiotic, has similar antimicrobial spectrum to erythromycin but better in vitro MIC90 (0.03 microgram/l-1) against Helicobacter pylori (H pylori). This study aimed at determining the eradication rate using clarithromycin 500 mg thrice daily omeprazole 40 for two weeks. Patients were given an endoscopy H status assessed by antral culture (microaerobic conditions, up 10 days), corpus histology tests (haematoxylin eosin/Gimenez stains), 13C-urea breath test (13C-UBT, European standard protocol, positive result = excess delta 13CO2 excretion > 5 per mil). Compliance was returned tablet counts. clearance end of treatment four weeks after finishing 13C-UBT. Seventy three patients (54 men, median age 45 years) with duodenal ulcers (n 42) or duodenitis/non-ulcer dyspepsia 31) all 13C-UBT (mean (SEM) delta-13CO2 26.6 (4.9) mil) either 72) 35) studied. Before 2/27 (7%) isolates resistant five metronidazole. In 70/73 (96%) negative immediately treatment. Four later 57/73 1.2 (0.3) mil, 78%). Forty eight (66%) experienced metallic taste while taking tablets. Although (5%) patients, however, could not complete course treatment, only one these eradicated. These results show that duel therapy is tolerated. With 78% it effective metronidazole may be alternative triple therapy.