Effectiveness of the macrolide clarithromycin in the treatment of Mycobacterium avium complex infection in HIV-infected patients

摘要: In a randomized double-blind study, nine mycobacteremic patients with AIDS-related disseminatedMycobacterium avium complex (MAC) infection received clarithromycin or placebo in addition to basic regimen that included isoniazid, ethambutol and clofazimine. All four receiving showed blood culture conversion clinical response. Of the five treated without clarithromycin, two resolution of mycobacteremia reponse, while another died having shown The remaining patient deteriorated until switch from led rapid improvement. After finishing six weeks intensive treatment, was given an open maintenance phase all patients, initially combination rifabutin for 24 then alone. One had relapse MAC associated acquired resistance drug. Clarithromycin appears be promising component multi-drug therapy infection. Monotherapy can lead drug resistance.