Quantification of experimental myocardial infarction using nuclear magnetic resonance imaging and paramagnetic ion contrast enhancement in excised canine hearts.

摘要: Determination of myocardial infarct size is important for clinical management patients with ischemic heart disease and research on limiting size. Nuclear magnetic resonance (NMR) imaging permits tomographic depiction the distribution mobile tissue protons. NMR images have demonstrated high spatial resolution contrast. To evaluate potential this technique in measuring size, was performed six canine hearts excised 24 hours after circumflex coronary artery ligation. Before sacrifice, dogs received i.v. manganous chloride (0.05 mmol/kg). After imaging, were sectioned slices stained triphenyl tetrazolium chloride. The pathologically determined compared measured by imaging. correlation good (regression line slope 1.06; r = 0.94). We conclude that paramagnetic contrast agents can be used to determine hearts.