Nationwide outbreak of red eye syndrome associated with transfusion of leukocyte-reduced red blood cell units.

摘要: OBJECTIVE. To characterize red eye reactions occurring within 24 hours after receipt of units leukocyte-reduced blood cells, determine their etiology, and investigate potential link to transfusion. METHODS. We conducted a survey transfusion facilities nationwide the scope magnitude reactions; performed case-control cohort studies among transfused patients at facility where most occurred; animal experiments, using cellulose acetate derivatives extracted from leukocyte-reduction filters filter precursors, reproduce reactions. RESULTS. From January 1, 1997, through 15, 1998, we identified 159 in 117 17 states. Reactions were characterized by conjunctival erythema or hemorrhage (in 100% patients), pain 62%), photophobia 46%), decreased visual acuity 32%). Symptom onset occurred 1-24 initiation resolved median 5 days. associated with sessions that included cells filtered specific brand filter, LeukoNet (HemaSure) (odds ratio, 100.4; P<.001). There was dose-response relationship between number LeukoNet-filtered attack rate for reactions, ranging 0.8% which 1 unit 27.3% 3 more (P<.001). A similar ocular syndrome elicited rabbits injected unused precursors. No reported withdrawn market. CONCLUSIONS. This transfusion-associated linked likely resulted leached membrane.