Implantation of non-toxic materials from glucose sensors: evidence for specific antibodies detected by ELISA.

摘要: After subcutaneous implantation of glucose sensors into LEW.1A rats, antibodies could be detected by means enzyme-linked immunosorbent assay against the outer membrane (cellulose acetate) but not either inner (polyethylene) or oxidase (GOD). The kinetics humoral immune response were investigated implanting different polymeric membranes such as polyurethane, cellulose acetate, regenerated cellulose. highest antibody titer was There no cytotoxic effect in vitro any tested materials examined on monolayer cultures mouse fibroblast cell line L-929. Thus immunogenicity is suggested to considered a parameter biocompatibility testing implantable medical devices.