Prediction of clinical course of diffusely infiltrating astrocytomas from telomerase expression and quantitated activity level.
作者： Takao Fukushima , Atsuo Yoshino , Yoichi Katayama , Takao Watanabe , Kaoru Kusama
DOI: 10.1016/S0304-3835(02)00357-9
关键词:
摘要: Telomerase, one of the reverse transcriptases that extend telomere length, has been suggested to facilitate tumorigenesis and tumor immortality. Little is yet known, however, concerning clinical significance telomerase expression in brain tumors. We found present study may contribute malignant progression can be an important indicator high grade diffusely infiltrating astrocytomas, its quantitated activity level reflects their growth potential. Telomerase are also a good predictor course as compared with other biological markers factors.
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sci-hub.se 参考文章(43)
Andrzej Bednarek, Irina Budunova, Thomas J Slaga, C Marcelo Aldaz, Increased Telomerase Activity in Mouse Skin Premalignant Progression Cancer Research. ,vol. 55, pp. 4566- 4569 ,(1995)
Yonehiro Kanemura, Hirotaka Matsumura, Shoju Hiraga, Norio Arita, Takanori Ohnishi, Eiji Miyahara, Shuichi Izumoto, Telomerase Activity and Alterations in Telomere Length in Human Brain Tumors Cancer Research. ,vol. 58, pp. 2117- 2125 ,(1998)
C A Finlay, P W Hinds, T H Tan, D Eliyahu, M Oren, A J Levine, Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Molecular and Cellular Biology. ,vol. 8, pp. 531- 539 ,(1988) , 10.1128/MCB.8.2.531
Mieczyslaw A. Piatyszek, Naokuni Tatsumoto, Takashi Kodama, Eiso Hiyama, Takashi Yokoyama, Yoshiaki Murakami, Jerry W. Shay, Yuji Imamura, Yuichiro Matsuura, Keiko Hiyama, Telomerase activity in gastric cancer. Cancer Research. ,vol. 55, pp. 3258- 3262 ,(1995)
Silvia Bacchetti, Hal W. Hirte, Kazy Hay, Steven Gallinger, Corinne Chadeneau, Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Research. ,vol. 55, pp. 2533- 2536 ,(1995)
Tarik Tihan, Ute Moll, Raphael Davis, Damian DiCostanzo, Eric Elowitz, Practical Value of Ki-67 and p53 Labeling Indexes in Stereotactic Biopsies of Diffuse andPilocytic Astrocytomas Archives of Pathology & Laboratory Medicine. ,vol. 124, pp. 108- 113 ,(2000) , 10.1043/0003-9985(2000)124<0108:PVOKAP>2.0.CO;2
Kei Nakatani, Naoki Yoshimi, Hideki Mori, Shin-ichi Yoshimura, Hideki Sakai, Jun Shinoda, Noboru Sakai, The Significant Role of Telomerase Activity in Human Brain Tumors Cancer. ,vol. 80, pp. 471- 476 ,(1997) , 10.1002/(SICI)1097-0142(19970801)80:3<471::AID-CNCR15>3.0.CO;2-U
E Jaros, RH Perry, L Adam, PJ Kelly, PJ Crawford, RM Kalbag, AD Mendelow, RP Sengupta, ADJ Pearson, Prognostic implications of p53 protein, epidermal growth factor receptor, and Ki-67 labelling in brain tumours. British Journal of Cancer. ,vol. 66, pp. 373- 385 ,(1992) , 10.1038/BJC.1992.273
C. M. Counter, H. W. Hirte, S. Bacchetti, C. B. Harley, Telomerase activity in human ovarian carcinoma. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 2900- 2904 ,(1994) , 10.1073/PNAS.91.8.2900
He Li, Ying Cao, Michael C Berndt, John W Funder, Jun-Ping Liu, Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro. Oncogene. ,vol. 18, pp. 6785- 6794 ,(1999) , 10.1038/SJ.ONC.1203061