Cross-sectional Associations of Medication and Supplement Use With Retinal Vascular Diameter in the Beaver Dam Eye Study

摘要: Importance Retinal vessel diameters are being measured to examine their relationship with ocular and systemic disease and, in some studies, calculate the risk of disease. Important factors that directly affect retinal diameters, such as medication use, should be considered when estimating these associations. Objective To quantify association between selected medications supplements diameters. Design, Setting, Participants In a prospective cohort investigation, 4926 participants (aged 43-86 years at baseline) Beaver Dam Eye Study were evaluated every 5 during 20 follow-up from 1988 2010. Main Outcomes Measures Central arteriolar equivalent central venular Early Treatment Diabetic Retinopathy fundus photograph field 1. Results After Bonferroni correction, use any blood pressure (β = 0.75; P  = .04), specifically calcium channel blockers (β = −1.02;  = .09); β-blockers  = .10) oral corticosteroids (β = 2.13;  = .07) marginally associated changes equivalent. Conclusions Relevance Several equivalents. Prostaglandin analogues, blockers, have largest relative effects. correction was applied, most strongly change The presence using diameter an outcome or measures assess