Genetics and Epigenetics of Head and Neck Cancer

摘要: Our ability to explore the cancer genome is dependent upon, and limited by, availability of representative tumour models, high-quality tissue resource capacity available technologies. Fortunately, there has been great progress in these areas recent years with next-generation sequencing techniques enabling entire sequencing, using a fraction resources previously required. Carcinogenesis multistep multifactorial process that involves multiple genes critical events occurring at DNA level highly stable macromolecule therefore an excellent for biomarker discovery. However, translational perspectives genomics remain which partly related intratumour heterogeneity, subclones cells can be present within same tumour. New advances therapy will rely upon greater understanding molecular basis this new therapies have target specific characteristics individual’s tumour, central modern concept personalised medicine. There however emerging classification HNSCC, prognostic significance, based presence human papillomavirus number genomic alterations present.