The molecular biology of head and neck cancer

摘要: Head and neck squamous cell carcinomas (HNSCCs) are caused by tobacco alcohol consumption infection with high-risk types of human papillomavirus (HPV). Tumours often develop within preneoplastic fields genetically altered cells. The persistence these after treatment presents a major challenge, because it might lead to local recurrences second primary tumours that responsible for large proportion deaths. Aberrant signalling pathways have been identified in HNSCCs inhibition epidermal growth factor receptor (EGFR) has proved successful therapeutic strategy. In this Review, we discuss the recent literature on tumour heterogeneity, field cancerization, molecular pathogenesis underlying causative cancer genes can be exploited novel personalized treatments patients HNSCC.