Optimization of Formulation Variables to Increase Antigen Entrapment in PLGA Particles
作者： Børge N. Fredriksen , Linn Benjaminsen Hølvold , Jarl Bøgwald , Roy A. Dalmo
DOI: 10.1080/03602559.2012.715358
关键词:
摘要: Efficient antigen entrapment is a key factor in preparation of poly (lactide-co-glycolide) acid (PLGA) vaccine formulations when the short supply. This study presents systematic approach testing formulation variables with objective to increase particles stock concentration was low. Some experimental tested were (vinyl) alcohol (PVA) inner (W1) and outer (W2) aqueous phase, W1/oil (O) phase ratio choice organic solvent. The double emulsion solvent evaporation technique applied prepare PLGA sonication as emulsifying force. To measure efficiency, (bovine serum albumin, BSA) isotope labeled 125iodine (125I). Our results demonstrated that low PVA beneficial achieve high encapsulation efficiency antigen. On contrary, concen...
sci-hub.se 参考文章(42)
Hayley Jeffery, Stanley S. Davis, Derek T. O'Hagan, The preparation and characterization of poly(lactide-co-glycolide) microparticles. II: The entrapment of a model protein using a (water-in-oil)-in-water emulsion solvent evaporation technique Pharmaceutical Research. ,vol. 10, pp. 362- 368 ,(1993) , 10.1023/A:1018980020506
Duane T Birnbaum, Jacqueline D Kosmala, David B Henthorn, Lisa Brannon-Peppas, None, Controlled release of β-estradiol from PLAGA microparticles:: The effect of organic phase solvent on encapsulation and release Journal of Controlled Release. ,vol. 65, pp. 375- 387 ,(2000) , 10.1016/S0168-3659(99)00219-9
M. E. Christine Lutsiak, Glen S. Kwon, John Samuel, Biodegradable nanoparticle delivery of a Th2-biased peptide for induction of Th1 immune responses. Journal of Pharmacy and Pharmacology. ,vol. 58, pp. 739- 747 ,(2010) , 10.1211/JPP.58.6.0004
Sergio Freitas, Hans P. Merkle, Bruno Gander, Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology Journal of Controlled Release. ,vol. 102, pp. 313- 332 ,(2005) , 10.1016/J.JCONREL.2004.10.015
YASUAKI OGAWA, MASAKI YAMAMOTO, HIROAKI OKADA, TAKATSUKA YASHIKI, TSUGIO SHIMAMOTO, A New Technique to Efficiently Entrap Leuprolide Acetate into Microcapsules of Polylactic Acid or Copoly(Lactic/Glycolic) Acid Chemical & Pharmaceutical Bulletin. ,vol. 36, pp. 1095- 1103 ,(1988) , 10.1248/CPB.36.1095
Luis J. Cruz, Paul J. Tacken, Fernando Bonetto, Sonja I. Buschow, Huib J. Croes, Mietske Wijers, I. Jolanda de Vries, Carl G. Figdor, Multimodal imaging of nanovaccine carriers targeted to human dendritic cells. Molecular Pharmaceutics. ,vol. 8, pp. 520- 531 ,(2011) , 10.1021/MP100356K
Huang Yushu, Subbu Venkatraman, The effect of process variables on the morphology and release characteristics of protein-loaded PLGA particles Journal of Applied Polymer Science. ,vol. 101, pp. 3053- 3061 ,(2006) , 10.1002/APP.23933
M. Cho, H. Sah, Formulation and process parameters affecting protein encapsulation into PLGA microspheres during ethyl acetate-based microencapsulation process Journal of Microencapsulation. ,vol. 22, pp. 1- 12 ,(2005) , 10.1080/02652040400026269
D.K. Sahana, G. Mittal, V. Bhardwaj, M.N.V.Ravi Kumar, PLGA Nanoparticles for Oral Delivery of Hydrophobic Drugs: Influence of Organic Solvent on Nanoparticle Formation and Release Behavior In Vitro and In Vivo Using Estradiol as a Model Drug Journal of Pharmaceutical Sciences. ,vol. 97, pp. 1530- 1542 ,(2008) , 10.1002/JPS.21158
Samar Hamdy, Praveen Elamanchili, Aws Alshamsan, Ommoleila Molavi, Tadaaki Satou, John Samuel, Enhanced antigen-specific primary CD4+ and CD8+ responses by codelivery of ovalbumin and toll-like receptor ligand monophosphoryl lipid A in poly(D,L-lactic-co-glycolic acid) nanoparticles. Journal of Biomedical Materials Research Part A. ,vol. 81, pp. 652- 662 ,(2007) , 10.1002/JBM.A.31019