Association Between Epidermal Growth Factor Polymorphism and Esophageal Squamous Cell Carcinoma Susceptibility

摘要: Genetic factors are known to be important in the development of esophageal squamous cell carcinoma (ESCC). Epidermal growth factor (EGF) can activate several signaling pathways leading proliferation, differentiation, and tumorigenesis epithelial tissues by binding with its receptor. Interindividual variations EGF production were genetically contributed +61 G/A polymorphism. The purpose this study is investigate potential association between gene polymorphism ESCC a Chinese population. In study, we analyzed single nucleotide 158 patients 212 age- sex-matched controls population using polymerase chain reaction-restriction fragment length (PCR-RFLP) strategy DNA sequencing. variant genotypes GA/AA associated significantly decreased risk compared wild-type homozygote GG (OR = 0.657, 95% CI: 0.434-0.996). However, no significant difference was observed when analyses stratified terms age, gender, smoking status, different clinical stage, lymph node status. Our data suggests that may play role ESCC.