Elevated RABEX-5 protein expression predicts poor prognosis in combined small cell lung cancer
作者： Fuliang Zhang , Meng Zhang , Guohua Hu , Qiling Cai , Tongbai Xu
DOI: 10.1007/S13277-015-3562-4
关键词:
摘要: RABEX-5 has been studied in various solid tumors, but its role combined small cell lung cancer (C-SCLC) remains unknown. This study aimed to investigate the expression, potential relevance clinicopathological characters and prognostic significance of patients with C-SCLC. Fifty-two C-SCLC who received radical surgery were enrolled our study. The clinicalpathological data survival time reviewed. mRNA protein expression from paired tumor tissues adjacent normal determined, relationship variables prognosis was analyzed. Univariate multivariate analyses performed for level significantly elevated tissues. increased correlated clinical stage (p = 0.011) recurrence 0.006). median OS DFS shorter high group compared low (OS: 12.0 vs. 21.7 months, p 0.014; DFS: 6.7 11.8 0.005). Multivariate Cox analysis indicated that an independent factor < 0.001). is a useful indicator predicts poor long-term C-SCLC, which should be considered defining other well-known prognosticators patients.
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