CYP1A1 MspI and exon7 gene polymorphisms and lung cancer risk: an updated meta-analysis and review.

摘要: Many studies have examined the association between CYP1A1 MspI and exon 7 gene polymorphisms lung cancer risk in various populations, but their results been inconsistent. To assess this relationship more precisely, a meta-analysis review were performed. The PubMed, Embase, Web of Science, CNKI database was searched for case-control published up to June 2010. Data extracted pooled odds ratios (OR) with 95% confidence intervals (CI) calculated. Ultimately, 64 studies, comprising 18,397 subjects from 49 genotype 18,518 patients 40 genotype, included. A significantly elevated associated 2 variants (for type C vs Type A: OR = 1.26, CI 1.12-1.42; types B combined 1.20, 1.13-1.28) overall population. In stratified analysis, significant found Asians, Caucasians, SCC, AC Male population, not mixed SCLC Female However, inconsistent observed exon7 our meta-analysis, two polymorphism higher Val/Val Ile/Ile: 1.24, 1.09-1.42; (Ile/Val +Val/Val) 1.15, 1.07-1.24) assocation SCC AD, Additionally, smoker population non-smoker populations gene. This suggests that correlate increased susceptibility there is an interaction genotypes smoking, these associations vary different ethnic histological caner gender case control