Malignant melanoma in pregnancy. A population-based evaluation.

摘要: BACKGROUND For many years, there has been controversy in the medical community regarding correlation of female hormonal factors with outcome women malignant melanoma. There have multiple reports that high hormone states, such as pregnancy, had thicker tumors and/or a worse prognosis compared group control women. METHODS The authors used database contained maternal and neonatal discharge records from entire state California 1991 to 1999 linked those Cancer Registry, which maintains legally mandated all cancers reported during same time period. Four hundred twelve melanoma diagnosed or within 1 year after pregnancy were identified (145 antepartum, 4 at delivery, 263 postpartum) age-matched, nonpregnant (controls). The captured only pregnancies ≥ 20 weeks gestation. RESULTS When comparing who pregnancy-associated group, found no difference distribution disease stage (82.0% pregnant postpartum localized vs. 81.9% women) tumor thickness (mean: 0.77 mm for women, 0.90 0.81 group). In regression model controlled age, race, stage, thickness, impact on survival Lymph node assessment positivity lymph nodes also equivalent between two groups. Maternal outcomes did not differ history malignancy. Small numbers advanced inability capture occurred lost terminated prior limited conclusions primarily melanoma. CONCLUSIONS In this large, population-based study melanoma, data support more tumors, increased metastases nodes, worsened survival. associated was excellent. without 2005. © 2005 American Society.