Severe, primary dysmenorrhea treated with naproxen. A prospective, double-blind, crossover investigation.

摘要: 26 women aged 15-45 with severe, primary dysmenorrhea were treated naproxen (NAPROSYN, SYNTEX) and placebo during 2 x consecutive menstrual cycles in a randomized, double-blind crossover study. The dosage of was 500 mg (2 tablets) initially, followed by 250 as needed, maximum 1250 daily. In most cases medication started at the first sign distress. 80 per cent preferred to placebo. number tablets taken each menstruation fell from mean 17.8 period 5.1 period. Likewise, additional analgesics 7.1 1.6 hours bed rest 16.4 1.2. Total days sick leave two menstruations decreased 40 7. These differences are statistically significant (P < 0.001). side effects mild. CNS or gastrointestinal not seen. Naproxen changed amount bleeding 12 delayed three. Two developed acne, which however gradually diminished next five periods naproxen. influence prostaglandin synthetase inhibitors on ovarian production steroids is discussed.