Probing the physical limits of reliable DNA data retrieval.

作者: Lee Organick , Yuan-Jyue Chen , Siena Dumas Ang , Randolph Lopez , Xiaomeng Liu

DOI: 10.1038/S41467-020-14319-8

关键词:

摘要: Synthetic DNA is gaining momentum as a potential storage medium for archival data storage. In this process, digital information translated into sequences of nucleotides and the resulting synthetic strands are then stored later retrieval. Here, we demonstrate reliable file recovery with PCR-based random access when few ten copies per sequence stored, on average. This results in density about 17 exabytes/gram, nearly two orders magnitude greater than prior work has shown. We successfully retrieve same complex pool over 1010 unique microliter no evidence that have begun to approach complexity limits. Finally, also investigate effects size sequencing coverage successful retrieval look systematic strand drop out. These findings substantiate robustness high process examined here.

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