Colorectal cancer in Chinese patients: current and emerging treatment options.
作者： Brigette Ma , Leung Li
DOI: 10.2147/OTT.S48409
关键词:
摘要: Colorectal cancer is the second most common in Hong Kong and its incidence rising economically developed Chinese cities, including Shanghai. Several studies conducted People’s Republic of China have characterized unique molecular epidemiology familial colorectal syndromes biomarkers such as microsatellite instability genetic mutations (eg, KRAS, NRAS, BRAF, PIK3CA, ERCC1) populations. Interethnic differences anticancer drug response toxicity been well described many cancers, this review examined literature with regard to tolerance patients commonly used chemotherapeutic regimens targeted therapies for metastatic cancer. Studies on pharmacogenomic metabolizing DNA repair enzymes between Chinese, North Asians, Caucasian were also reviewed.
doaj.org参考文章(122)
Xiao-Rong Liu, Xiang-Nian Shan, W Friedl, S Uhlhaas, Jin-Tian Li, P Propping, Ya-Ping Wang, None, Detection of germline mutations in the APC gene with the protein truncation test Acta Genetica Sinica. ,vol. 32, pp. 903- ,(2005)
Lin Shen, Jing Gao, Yan-yan Li, Zhi-wei Sun, [Mutations of KRAS and BRAF in Chinese patients with colorectal carcinoma: analyses of 966 cases]. Chinese Journal of Pathology. ,vol. 41, pp. 579- 583 ,(2012) , 10.3760/CMA.J.ISSN.0529-5807.2012.09.002
Xu-Lin Wang, Clinical and genetic characteristics of Chinese hereditary nonpolyposis colorectal cancer families. World Journal of Gastroenterology. ,vol. 12, pp. 4074- 4077 ,(2006) , 10.3748/WJG.V12.I25.4074
Xu Cai, Fei Yang, Ling Zhang, Xiang Du, Xiao Yan Zhou, Yong Ming Lu, Wei Qi Sheng, Xiao Li Zhu, KRAS and BRAF gene mutations in correlation with clinicopathologic features of colorectal carcinoma in Chinese Chinese Journal of Pathology. ,vol. 41, pp. 584- 589 ,(2012) , 10.3760/CMA.J.ISSN.0529-5807.2012.09.003
Li Gong Xu, Zi Yi Zhao, Jia Cheng, Qing Wu, Chang Ping Wu, Nong Xu, Wen Zhang, Jin Li, Multicenter phase II study of modified FOLFIRI regimen in the advanced colorectal cancer patient refractory to fluoropyrimidine and oxaliplatin Chinese journal of oncology. ,vol. 28, pp. 788- 790 ,(2006)
Changqing Yang, Haihui Sheng, Hengjun Gao, Haina Chai, Xiaoying Shen, Hang Li, Kehao Zhang, Jie Pan, Xuelin Zhang, Xiaoyan Zhang, ERCC1 C118T associates with response to FOLFOX4 chemotherapy in colorectal cancer patients in Han Chinese. International Journal of Clinical and Experimental Medicine. ,vol. 5, pp. 186- 194 ,(2012)
Qi Cai, Clinicopathological and molecular genetic analysis of 4 typical Chinese HNPCC families World Journal of Gastroenterology. ,vol. 7, pp. 805- 810 ,(2001) , 10.3748/WJG.V7.I6.805
Brigette B. Y. Ma, Stephen L. Chan, Wing M. Ho, Wilson Lau, Frankie Mo, Edwin P. Hui, Charles Chan, Annette Poon, Rasalkar D. Dattatray, S. C. Cesar Wong, Ka F. To, Ann D. King, Anil Ahuja, Anthony T. C. Chan, Intermittent versus continuous erlotinib with concomitant modified "XELOX" (q3W) in first-line treatment of metastatic colorectal cancer: correlation with serum amphiregulin and transforming growth factor alpha. Cancer. ,vol. 119, pp. 4145- 4153 ,(2013) , 10.1002/CNCR.28327
Ming‐Yii Huang, Hsiang‐Lin Tsai, Chih‐Hung Lin, Ching‐Wen Huang, Cheng‐Jen Ma, Chun‐Ming Huang, Chee‐Yin Chai, Jaw‐Yuan Wang, None, Predictive value of ERCC1, ERCC2, and XRCC1 overexpression for stage III colorectal cancer patients receiving FOLFOX-4 adjuvant chemotherapy. Journal of Surgical Oncology. ,vol. 108, pp. 457- 464 ,(2013) , 10.1002/JSO.23422
Yuan-Zhi Zhang, Clinical phenotype and prevalence of hereditary nonpolyposis colorectal cancer syndrome in Chinese population World Journal of Gastroenterology. ,vol. 11, pp. 1481- 1488 ,(2005) , 10.3748/WJG.V11.I10.1481