Molecular Subtypes of Colorectal Cancer and Their Clinicopathologic Features, With an Emphasis on the Serrated Neoplasia Pathway

摘要: Context.—Colorectal cancer is a heterogeneous disease entity with 3 molecular carcinogenesis pathways and 2 morphologic multistep pathways. Right-sided colon cancers left-sided rectal exhibit differences in their incidence rates according to geographic region, age, sex. A linear tendency toward increasing frequencies of microsatellite instability–high or CpG island methylator phenotype–high subsites along the bowel from rectum cecum ascending accounts for tumor phenotypes associated these subsites. The subtypes colorectal different responses adjuvant therapy, which might be responsible subtype-specific survival. Objectives.—To review clinicopathologic features generated by combined phenotype statuses, integrate most recent findings co...