The Significance of Serum Interleukin-8 in Acute Exacerbations of Chronic Obstructive Pulmonary Disease.

摘要: Backgrounds Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is closely related to mortality. Systemic inflammation considered be involved in the pathogenesis AECOPD. The current study aimed investigate clinical significance classic chemokine interleukin (IL)-8 serum during Materials and Methods In this cross sectional, observational study, 50 patients with AECOPD, 25 stable COPD healthy nonsmokers as control group were selected. Clinical characteristics spirometry data collected. All classified grade 1-4 based on forced expiratory volume 1 second (FEV1) after bronchodilation according GOLD severity classification divided into frequent (FE) (≥2 times/year) non-frequent (NFE) (<1 time/year) acute (AE) times previous 12 months before visit. IL-8, IL-6, tumor necrosis factor (TNF)-α, superoxide dismutase levels measured by enzyme-linked immunosorbent assay technique. Results Serum IL-8 increased sequentially from controls [9.45 pg/mL (ranged: 6.85-38.4)], [51.60 22.4-131.1)], stage [129 57.7-374)]. level was significant higher FE than that NFE (209.0 115-472) vs 65.6 11.2-149.3), P=0.008). A receiver operating curve (ROC) generated evaluate TNF-α discriminate between without showed total area under (AUC) 0.71 (95% confidence interval (CI): 0.5764-0.8381; P=0.003), 0.54 (95%CI: 0.4048-0.6943; P=0.54), 0.52 0.3912-0.6656; P= 0.7). Conclusion a sensitive, easy-to-measure, inexpensive biomarker give an indication course exacerbation, target explored further predictor distinguish prone exacerbation.