Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation.

摘要: Summary Background Oxidative stress and inflammation play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Objective Pulmonary function, oxidative parameters inflammatory markers were measured 74 patients with severe COPD exacerbation 41 healthy subjects. In all assessed at two time points: Firstly, one day after admission secondly, 7 10 days when they clinically stable enough to be discharged. Patients divided groups according presence ischemic heart (IHD): IHD positive (IHD+) negative (IHD-) patients. Methods Results During hospitalisation 02•−, malondialdehyde (MDA), advanced oxidation protein products (AOPP) total oxidant status (TOS) increased higher discharge compared control group. Superoxide dismutase (SOD) activity was significantly lower both points Total antioxidant (TAS) prooxidant-antioxidant balance (PAB) High sensitive C-reactive (hsCRP) also neutrophil count discharge. Paraoxonase 1 (PON1) enzymatic activities did not differ IHD+ had PON1 but PAB levels hsCRP concentrations, Conclusion The oxidant/antioxidant imbalance pronounced for least 24 hours following their Increased stress, elevated systemic decreased defence common end-stage particularly disease.