Reply to 'LMP2 expression and proteasome activity in NOD mice'

摘要: In our paper, we described developmentally expressed defects in splenocytes and macrophages NF-B activation LMP2 expression the NOD mouse4. These parallel disease expression, which occurs 30% of males 70% females by 30 weeks age13, emphasized that such abnormalities are never seen early life. contrast, others have reported normal or augmented proteasome activity target tissue autoimmune mice4, 14. Thus, phenotypic derangements depend on gender, age, course individual mice.