Immunoproteasomes at the interface of innate and adaptive immune responses: two faces of one enzyme

摘要: The immunoproteasome is a specific proteasome isoform induced by interferons. Its proteolytic function has been almost exclusively connected with the adaptive immune response and improved MHC class I antigen presentation. However, IFN-signaling also exposes cells to oxidative stress concomitant production of nascent-oxidant damaged poly-ubiquitylated proteins. Here we discuss how immunoproteasomes protect against accumulation toxic protein-aggregates i-proteasomes dysfunction associates different diseases. We propose that central at interface between innate its predominant protective determines favorable role in response.