Neurodevelopmental processes in schizophrenia and schizotypal personality disorder

摘要: This chapter offers some speculations on the neuropathological substrate that gives rise to both schizotypal personality disorder (SPD) and schizophrenia. It examines developmental phenomenology of schizophrenia SPD. Research biological offspring schizophrenic patients indicates those who are diagnosed with SPD in adulthood showed neuromotor abnormalities infancy. A comprehensive neurodevelopmental model any must account for its changing manifestations dysfunction across life course. In case schizophrenia, evidence particular, dyskinesia is most pronounced early late course, florid psychotic symptoms adulthood. Differences between may be revealed by positron emission tomography (PET) studies receptor activity limbic striatum. Postmortem investigations performed identify differences myelination cytoarchitectonics circuitry.