GB virus C: insights into co-infection.

摘要: GB virus C (GBV-C) is a single stranded positive sense RNA virus, which member of the Flaviviridae. It has close sequence homology and genomic organisation to hepatitis (HCV). However, unlike HCV it not hepatotrophic. GBV-C replicates within cells haemopoietic lineage, in particular lymphocytes. No disease been associated with infection but co-infection human immunodeficiency (HIV) leads improved morbidity mortality for HIV infected individual slows progression acquired syndrome. This potential benefit demonstrated pre post highly active anti-retroviral treatment (HAART) eras. found decrease replication vitro models. The mechanism beneficial effect appears be mediated by alterations cellular immune response, details remain unclear. Despite this, there continues controversy regarding influence on as several reports have questioned effect. does appear liver related subjects co-infected or B (HBV). Combination accelerated disease. this situation yet determined. Elucidation putative protective could potentially identify novel targets anti-HIV therapeutics lead development modifying vaccines.