B cell positive cross-match not due to anti-HLA Class I antibodies and first kidney graft outcome.
作者： Loredana Praticò-Barbato , Raffaele Conca , Paola Magistroni , Gianluca Leonardi , Alice Oda
DOI: 10.1016/J.TRIM.2008.05.002
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摘要: Abstract The effect of B cell cross-match (XM) was investigated in 680 first deceased-donor kidney transplants a single centre from 1990 to 1999: 74 presented B-positive XM (Group 1) 606 had B-negative 2). absence Group 1 weak/low-titre anti-HLA Class I antibodies assured blocking anti-Class reactivity by treating cells with non-cytotoxic anti-s2 microglobulin (αβ2 M) serum before XM. Graft survivals up 5 years were not significantly different; some differences nevertheless observed: HLA-A,B,DR mismatches influenced graft outcome 1: patients 0–2 better survival than 3–4. When analysed according DR mismatch, mismatch worse well matched (p Anti-donor reactivity, at XM, once excluded the presence antibodies, did influence survival.
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