Expression of basic fibroblastic growth factor, syndecan 1 and tumour necrosis factor α in resected acute colonic diverticulitis
作者： A. Tursi , W. Elisei , G. M. Giorgetti , C. D. Inchingolo , R. Nenna
DOI: 10.1111/CODI.12504
关键词:
摘要: Aim Inflammation and fibrosis are present in both colonic diverticulitis Crohn's disease (CD). The molecular pattern of basic fibroblastic growth factor (bFGF) syndecan 1 (SD1) expression is altered stenosing CD, but their resected complicated (ACD) unknown. Method The bFGF, SD1 tumour necrosis α (TNF-α) 20 patients after resection ACD was compared with 15 having a for CD. Analysis conducted using real-time reverse transcriptase polymerase chain reaction biopsy samples. Results Lymphocytic neutrophil inflammation scores were similar groups (P = 0.771 P = 0.562). TNF-α bFGF significantly higher than CD (P < 0.0001 P = 0.009). (P = 0.841). Conclusion TNF-α overexpressed respect to whilst levels do not differ. findings confirm that its association patterns mucosal healing may play an important role the phenotype diseases.
sci-hub.se 参考文章(34)
F J Vizoso, L O González, M D Corte, J C Rodríguez, J Vázquez, M L Lamelas, S Junquera, A M Merino, J L García-Muñiz, Study of matrix metalloproteinases and their inhibitors in breast cancer. British Journal of Cancer. ,vol. 96, pp. 903- 911 ,(2007) , 10.1038/SJ.BJC.6603666
Martin JW Meijer, Marij AC Mieremet-Ooms, AM Van Der Zon, Wim van Duijn, Ruud A van Hogezand, Cornelis FM Sier, Daniel W Hommes, Cornelis BHW Lamers, Hein W Verspaget, None, Increased mucosal matrix metalloproteinase-1, -2, -3 and -9 activity in patients with inflammatory bowel disease and the relation with Crohn's disease phenotype. Digestive and Liver Disease. ,vol. 39, pp. 733- 739 ,(2007) , 10.1016/J.DLD.2007.05.010
Antonio Altadill, Noemí Eiró, Luis Ovidio González, Sara Junquera, José Manuel González-Quintana, María Rosario Sánchez, Alejandro Andicoechea, Cristina Saro, Luis Rodrigo, Francisco José Vizoso, Comparative analysis of the expression of metalloproteases and their inhibitors in resected crohn's disease and complicated diverticular disease. Inflammatory Bowel Diseases. ,vol. 18, pp. 120- 130 ,(2012) , 10.1002/IBD.21682
Antonio Tursi, Segmental Colitis Associated with Diverticulosis: Complication of Diverticular Disease or Autonomous Entity? Digestive Diseases and Sciences. ,vol. 56, pp. 27- 34 ,(2011) , 10.1007/S10620-010-1230-5
A. Tursi, W. Elisei, G. Brandimarte, G. M. Giorgetti, C. D. Inchingolo, R. Nenna, M. Picchio, F. Giorgio, E. Ierardi, Musosal tumour necrosis factor α in diverticular disease of the colon is overexpressed with disease severity. Colorectal Disease. ,vol. 14, ,(2011) , 10.1111/J.1463-1318.2012.02926.X
Mark D. Baugh, Michael J. Perry, Anthony P. Hollander, D.Rhodri Davies, Simon S. Cross, Alan J. Lobo, Christopher J. Taylor, Gareth S. Evans, Matrix metalloproteinase levels are elevated in inflammatory bowel disease. Gastroenterology. ,vol. 117, pp. 814- 822 ,(1999) , 10.1016/S0016-5085(99)70339-2
Ian Craig Lawrance, Lesley Maxwell, William Doe, Altered response of intestinal mucosal fibroblasts to profibrogenic cytokines in inflammatory bowel disease. Inflammatory Bowel Diseases. ,vol. 7, pp. 226- 236 ,(2001) , 10.1097/00054725-200108000-00008
Paul L. Beck, Daniel K. Podolsky, Growth factors in inflammatory bowel disease. Inflammatory Bowel Diseases. ,vol. 5, pp. 44- 60 ,(1999) , 10.1097/00054725-199902000-00007
Enzo Ierardi, Floriana Giorgio, Rosa Rosania, Mariangela Zotti, Simonetta Prencipe, Nicola Della Valle, Vincenzo De Francesco, Carmine Panella, Mucosal assessment of tumor necrosis factor alpha levels on paraffined samples: a comparison between immunohistochemistry and real time polymerase chain reaction Scandinavian Journal of Gastroenterology. ,vol. 45, pp. 1007- 1008 ,(2010) , 10.3109/00365521.2010.483739
Richard Day, Alastair Forbes, Heparin, cell adhesion, and pathogenesis of inflammatory bow el disease The Lancet. ,vol. 354, pp. 62- 65 ,(1999) , 10.1016/S0140-6736(98)09267-8