Chronic diverticulitis and Crohn's disease share the same expression of basic fibroblastic growth factor, syndecan 1 and tumour necrosis factor-α

摘要: It is well known that complicated diverticular disease (DD), which includes Acute Uncomplicated Diverticulitis (AUD), Complicated (ACD) and Chronic (CDiv), characterised by profound structural changes in the colonic tissue, varying from tissue disruption to fibrosis; it has been hypothesised an unbalanced expression of matrix metalloproteinases (MMP) their inhibitors (TIMP) protein bowel wall might, at least part, mediate this process.1 However, there limited knowledge about role MMPs pathogenesis diverticulitis. reported altered concentrations TIMPs may explain found diverticulitis.1 Crohn's (CD) a chronic inflammatory disorder gastrointestinal tract chronic, multifocal transmural inflammation potentially affecting whole tract, particularly ileocolonic segment. Altadill et al 2 recently CD DD seem share same destiny: evolving towards fibrosis. Adhesion molecules containing heparan sulfate (syndecan family) are proteo-glycans, play significant repair.3 Basic fibroblast growth factor (bFGF) peptide able …