Genomic organization of the human endogenous retrovirus HERV-K(HML-2.HOM) (ERVK6) on chromosome 7.

摘要: Recently, we reported an almost intact human endogenous retrovirus (HERV-K(HML-2.HOM); HGMW-approved symbol ERVK6) located on chromosome 7, with open reading frames for all retroviral genes and a mutation only within the reverse transcriptase. We further characterized genomic organization of this by subcloning sequencing proviral insert contained 7-specific cosmid clone found HERV-K(HML-2.HOM) to be organized as tandem repeat. Examination various DNA samples specific repeat suggests relatively ubiquitous distribution structure. However, identified two having single provirus at locus. In addition, investigated presence alleles YXDD motif transcriptase domain corresponding polymerase gene from samples. in samples, thus potentially coding active Our results show first time populations suggest existence harboring including gene.