Prophylaxis of postoperative endophthalmitis following cataract surgery: Results of the ESCRS multicenter study and identification of risk factors

摘要: Aims to identify risk factors and describe the effects of antibiotic prophylaxis on incidence postoperative endophthalmitis after cataract surgery based analysis findings European Society Cataract Refractive Surgeons (ESCRS) multicenter study. Setting: Twenty-four ophthalmology units in Austria, Belgium, Germany, Italy, Poland, Portugal, Spain, Turkey, United Kingdom. A prospective randomized partially masked study recruited 16 603 patients. The was a 2 × factorial design, with intracameral cefuroxime topical perioperative levofloxacin resulting 4 treatment groups. comparison case non-case data performed using multivariable logistic regression analyses. Odds ratios (ORs) associated other were estimated. Twenty-nine patients presented endophthalmitis, whom 20 classified as having proven infective endophthalmitis. absence an prophylactic regimen at 1 mg 0.1 mL normal saline 4.92-fold increase (95% confidence interval [CI], 1.87-12.9) for total In addition, use clear corneal incisions (CCIs) compared scleral tunnels 5.88-fold CI, 1.34-25.9) silicone intraocular lens (IOL) optic material acrylic 3.13-fold 1.47-6.67). presence surgical complications increased 4.95-fold 1.68-14.6), more experienced surgeons likely be cases. When considering only cases, IOL significantly risk, there evidence that men predisposed infection (OR, 2.70; 95% 1.07-6.8). Use end reduced occurrence Additional included CCIs IOLs.