Development of novel nanoparticles shelled with heparin for berberine delivery to treat Helicobacter pylori.

摘要: Various approaches have been proposed to overcome the unpleasant side-effects associated with antibiotic treatment for Helicobacter pylori. The limited effectiveness of such has forced researchers consider alternative strategies eliminate H. pylori infection. plant alkaloid berberine is known significantly reduce proliferation To localize site infection, this study developed a novel nanoparticle carrier heparin shell. Analysis simulated gastrointestinal medium indicated that in vitro drug system effectively controlled release berberine, which interacted specifically intercellular space at Furthermore, prepared nanoparticles increased suppressive effect on growth while efficiently reducing cytotoxic effects pylori-infected cells.