Vascular endothelial growth factor and the regulation of angiogenesis.

摘要: The development of a vascular supply is essential not only for organ and differentiation during embryogenesis but also wound healing reproductive functions in the adult Folkman, 1995). Angiogenesis implicated pathogenesis variety disorders: proliferative retinopathies, age-related macular degeneration, tumors, rheumatoid arthritis, psoriasis (Folkman, 1995; Garner, 1994). Several potential regulators angiogenesis have been identified, including fibroblast growth factor-a (aFGF), bFGF, transforming factor-alpha (TGF-alpha), TGF-beta, hepatocyte factor/scatter factor (HGF/SF), tumor necrosis (TNF-alpha), angiogenin, interleukin-8 (IL-8) (Folkman Shing, 1992; Risau, 1997). More recently, angiopoietins, ligands Tie-2 receptor (Suri et al., 1996; Maisonpierre 1997), identified. Vascular endothelial (VEGF) an endothelial-cell-specific mitogen. finding that VEGF was potent specific cells and, unlike freely diffusible, led to hypothesis this molecule plays unique role regulation physiological pathological (Ferrara Henzel, 1989: Leung 1989). Over last few years, several additional members gene family placenta (PIGF) (Maglione 1991,1993), VEGF-B (Olofsson 1996), VEGF-C (Joukov Lee VEGF-D (Orlandini 1996. Achen 1998). There compelling evidence cardiovascular system Davis-Smyth,