Hedgehog Signaling in Mammary Gland Development and Breast Cancer
作者： Adriana P. Visbal , Michael T. Lewis
DOI: 10.1007/978-1-4419-8435-7_9
关键词:
摘要: The Hedgehog signal transduction network is an essential regulator of metazoan embryonic development and functions in tissue homeostasis the adult. In mammary gland, this mediates epithelial–stromal interactions regulating branching morphogenesis histoarchitecture ducts, may control alveolar differentiation. Inappropriate activation associated with a wide variety cancers, including breast. Genetic evidence mice, as well molecular biological studies human cells, demonstrated that activated signaling can lead to hyperplasia and, some cases, tumor formation. However, mechanism(s) by which regulates normal gland development, exactly how contributes or progression breast cancer remain unclear. Because inappropriate observed activity cell self-renewal, has become leading candidate for targeted therapeutics.
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