Nanostructured delivery system for Suberoylanilide hydroxamic acid against lung cancer cells.
作者： Renu Sankar , Selvaraju Karthik , Natesan Subramanian , Venkateshwaran Krishnaswami , Jürgen Sonnemann
DOI: 10.1016/J.MSEC.2015.02.037
关键词:
摘要: Abstract With the objective to provide a potential approach for treatment of lung cancer, nanotechnology based Suberoylanilide hydroxamic acid (SAHA)-loaded Poly- d , l -lactide-co glycolide (PLGA) nanoparticles have been formulated using nanoprecipitation technique. The acquired were characterized by various throughput techniques and analyses showed presence smooth spherical shaped SAHA-loaded PLGA nanoparticles, with an encapsulation efficiency 44.8% particle size 208 nm. compatibility between polymer drug in formulation was tested FT-IR, Micro-Raman spectrum DSC thermogram analyses, revealing major interaction polymer. vitro release from found be biphasic initial burst followed sustained up 50 h. In experiments cancer cell line A549, demonstrated superior antineoplastic activity over free SAHA. conclusion, may useful novel cancer.
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