Antibacterial, sustained drug release and biocompatibility studies of electrospun poly (ε-caprolactone)/ chloramphenicol blend nanofiber scaffolds

摘要: Controlled drug release and antibacterial properties of electrospun nanofiber depend on slow molecules to the targeted area by diffusion embedded in nanofiber. In present study, chloramphenicol (CAP), an has been incorporated poly(e-caprolactone) (PCL) nanofibers weight content 5–20 wt% electrospinning. It was found that fiber diameter hydrophilic nature increased with increase CAP content. The latter phenomenon is expected facilitate biocompatibility scaffolds. scaffolds showed excellent against gram positive (Staphylococcus aureus Bacillus subtilis) as well negative (Escherichia coli, Pseudomonas aeruginosa Flavobacterium devorans) bacterial strains commonly associated wound burn infections. In-vitro studies were carried out phosphate buffer saline at pH ~ 7.4. be saturated about 20 days maximum ~80%. Nanofiber 5 highest rate among studied, which could attributed smaller this scaffold leading higher surface area. composite further studied for cell adhesion, proliferation toxicity using human colon colorectal epithelial cells (HCT 116 WT) vitro. are show adhesion both PCL large numbers. However, loaded better than neat counterpart.