Angiogenesis in preinvasive, early invasive bronchial lesions and micropapillomatosis and correlation with EGFR expression.
作者： A-P Meert , F Feoli , B Martin , V Ninane , J-P Sculier
DOI: 10.1111/J.1365-2559.2007.02610.X
关键词:
摘要: Aims: To study the association between morphological changes of bronchial epithelium and its angiogenic status evaluated by microvessel count (MVC), in order to gain a better understanding carcinogenesis. Also, correlate MVC with epidermal growth factor receptor (EGFR) expression. Methods results: Eighty-three biopsy specimens were assessed for MVC: four normal epithelia, 23 hyperplasias, 26 metaplasias, two mild dysplasias, five moderate nine severe three carcinomas situ, six early invasive squamous cell (EIC) cases micropapillomatosis. We observed statistically significant difference terms EIC all other subgroups micropapillomatosis subgroups. There was also EIC. did not observe any mucosa, dysplasias or carcinoma situ. EGFR expression higher dysplasia, situ EIC, whereas it very low A profile vs. MVC. increased an increase occurred only EIC. Conclusion: During carcinogenesis, except micropapillomatosis, appears be prerequisite neoangiogenesis
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sci-hub.se 参考文章(24)
Brian Fendly, Mien Chie Hung, Robert S. Kerbel, Alicia M. Viloria Petit, Patricia Rockwell, Neil Goldstein, Janusz Rak, Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. American Journal of Pathology. ,vol. 151, pp. 1523- 1530 ,(1997)
JUNICHI ASAKUMA, MAKOTO SUMITOMO, TAKAKO ASANO, TOMOHIKO ASANO, MASAMICHI HAYAKAWA, Modulation of Tumor Growth and Tumor Induced Angiogenesis After Epidermal Growth Factor Receptor Inhibition by ZD1839 in Renal Cell Carcinoma The Journal of Urology. ,vol. 171, pp. 897- 902 ,(2004) , 10.1097/01.JU.0000095445.79222.FF
A. Fisseler-Eckhoff, D. Rothstein, K.-M. M�ller, Neovascularization in hyperplastic, metaplastic and potentially preneoplastic lesions of the bronchial mucosa. Virchows Archiv. ,vol. 429, pp. 95- 100 ,(1996) , 10.1007/BF00192431
John Cooke, Haim Bitterman, Nicotine and angiogenesis: a new paradigm for tobacco‐related diseases Annals of Medicine. ,vol. 36, pp. 33- 40 ,(2004) , 10.1080/07853890310017576
Thomas Hellwig-Bürgel, Daniel P. Stiehl, Anika E. Wagner, Eric Metzen, Wolfgang Jelkmann, Review: Hypoxia-Inducible Factor-1 (HIF-1): A Novel Transcription Factor in Immune Reactions Journal of Interferon and Cytokine Research. ,vol. 25, pp. 297- 310 ,(2005) , 10.1089/JIR.2005.25.297
Gabriella Fontanini, Silvana Vignati, Daniela Bigini, Marco Lucchi, Alfredo Mussi, Fulvio Basolo, Carlo Alberto Angeletti, Generoso Bevilacqua, Neoangiogenesis: A putative marker of malignancy in non-small-cell lung cancer (NSCLC) development International Journal of Cancer. ,vol. 67, pp. 615- 619 ,(1996) , 10.1002/(SICI)1097-0215(19960904)67:5<615::AID-IJC4>3.0.CO;2-X
L Martin, B Green, C Renshaw, D Lowe, P Rudland, SJ Leinster, J Winstanley, Examining the technique of angiogenesis assessment in invasive breast cancer. British Journal of Cancer. ,vol. 76, pp. 1046- 1054 ,(1997) , 10.1038/BJC.1997.506
A-P. Meert, J-M. Verdebout, B. Martin, V. Ninane, F. Feoli, J-P. Sculier, Epidermal growth factor receptor expression in pre-invasive and early invasive bronchial lesions. European Respiratory Journal. ,vol. 21, pp. 611- 615 ,(2003) , 10.1183/09031936.03.00064902
Carl-Martin Fajers, Mesotheliomas of the genital tract; a report of five new cases and a survey of the literature. Apmis. ,vol. 26, pp. 1- 23 ,(2009) , 10.1111/J.1699-0463.1949.TB03142.X
Birgitte V. Offersen, Per Pfeiffer, Stephen Hamilton-Dutoit, Jens Overgaard, Patterns of angiogenesis in nonsmall-cell lung carcinoma. Cancer. ,vol. 91, pp. 1500- 1509 ,(2001) , 10.1002/1097-0142(20010415)91:8<1500::AID-CNCR1158>3.0.CO;2-M