Epidermal growth factor receptor expression in pre-invasive and early invasive bronchial lesions.

摘要: The 1999 World Health Organization/International Association for the Study of Lung Cancer histological classification preneoplastic bronchial lesions has been shown to be reproducible but little is known about its biological significance. current study evaluated correspondence between morphological changes epithelium and epidermal growth factor receptor (EGF-R) expression. Thirteen normal epithelia, 19 hyperplasia, 16 metaplasia, 10 mild dysplasia, one moderate severe dysplasia (SD), 14 carcinoma in situ (CIS) 11 microinvasive tumours were assessed. A global EGF-R score obtained by sum positivity plus staining intensity was calculated each lesion. >5 reached only six SD, CIS tumours. There no difference expression normal, hyperplastic metaplastic epithelia versus or there a statistically significant dysplasia. This demonstrates that rate with stage lesion, increasing from