Ethnicity/culture modulates the relationships of the haptoglobin (Hp) 1-1 phenotype with cognitive function in older individuals with type 2 diabetes.

摘要: Objective The haptoglobin (Hp) genotype has been associated with cognitive function in type 2 diabetes. Because ethnicity/culture both and Hp frequencies, we examined whether it modulates the association of function. Methods This cross-sectional study evaluated 787 cognitively normal older individuals (>65 years age) diabetes participating Israel Diabetes Cognitive Decline study. Interactions two-way analyses covariance compared Group (Non-Ashkenazi versus Ashkenazi Jews) on associations phenotype (Hp 1-1 non- 1-1) five outcome measures. The primary control variables were age, gender, education. Results Compared Jews, non-Ashkenazi Jews had significantly poorer than non-Hp domains Attention/Working Memory (p = 0.035) Executive Function (p = 0.023), but not Language/Semantic Categorization (p = 0.432), Episodic (p = 0.268), or Overall Cognition (p = 0.082). After controlling for additional covariates (type diabetes-related characteristics, cardiovascular risk factors, Mini-mental State Examination, extent depressive symptoms), (p = 0.038) (p = 0.013) remained significant. Conclusions Older from specific ethnic/cultural backgrounds may benefit more treatment targeted at decreasing halting detrimental effects brain. Future studies should examine differential impairment, especially groups high prevalence both, such as African–Americans Hispanics. Copyright © 2015 John Wiley & Sons, Ltd.