Myelin P0: New knowledge and new roles

摘要: Protein zero (P0) is an integral transmembrane glycoprotein that serves as the major protein component of peripheral nerve myelin and a member immunoglobulin (IgG) gene superfamily. As cell adhesion molecule, P0 mediates homophilic adhesive interactions between Schwann plasma membranes key structural constituent both dense line intraperiod compact myelin. Both extracellular cytoplasmic domains contribute to these evidence indicates post-translational modifications including glycosylation, acylation phosphorylation, play important modulatory role in likely proper trafficking from endoplasmic reticulum membrane well. Structural genetic studies indicate mutations producing human demyelinating diseases probably do so by perturbing or preventing during myelination, cellular toxicity unstable sheath. A variety transcription factors, growth factors neurosteroids directly indirectly influence expression maturation myelinating cell. Besides its function myelin, may have roles delivery other proteins their location, especially at near nodes Ranvier, neuronal-glial interactions.